Nathan Cain has been living with a rare condition since childhood that prevents him from feeling physical pain. Even serious injuries and fractures go unnoticed by him. In order to survive, he has learned to be cautious and stay away from trouble. During a bank robbery, the criminals kidnap the girl of his dreams. Now his innate characteristic is the only chance to save her. Thus begins the story of "Novocaine" - a tense action movie with elements of a thriller, where weakness becomes strength, and the instinct of self-preservation leads to a fight.