Wade Wilson is working at a mercenary in New York. Previously he has worked at a special force. During a party he meets Vanessa –a professional escort and their one night stand get converted into a relationship. They keep on dating for a year and then one day Wilson proposes her for marriage. He gets the news that he has a cancer in terminal stage on the same day.
He thinks that he should not meet Vanessaa any more and leaves her without telling anything. Wilson meets Jared from a covert Organization who assures Wilson of best treatment and cure for his cancer. Wilson is not interested first but then thinks that there is no harm in trying out the treatment. He enrols in the treatment program where he is sent to the lab located in remote area. Ajax and Angel Dust are working as doctors. Ajax injects a serum which has some properties of mutation activation.